PowerShell can access low-level API functions by using C#-style signatures. This way, API functions are compiled in-memory and added as new types. The example below uses an API function to lock the workstation:
$signature = '[DllImport("user32.dll",SetLastError=true)]
public static extern bool LockWorkStation();'
$t = Add-Type -memberDefinition $signature -name api -namespace stuff -passthru
$null = $t::LockWorkStation()
So the lock out the current user, run this:
PS C:\> Lock-WorkStation
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